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Dr. Maha Othman, MB BCh, PhD
Professor

Education

1990                       MD (MB BCh), Mansoura University, Egypt

1993                       Residency in Clinical Pathology, Mansoura University, Egypt

1995                       MSc in Clinical Pathology, Mansoura University, Egypt

2003                       PhD in Pathology, Southampton University, Southampton, UK

2005                       Post doctoral fellowship training, Queen’s University, CA

Career Overview

Dr. Othman is a Physician, Research Scientist, Educator and Mentor. She has strong passion for teaching and learning and is committed to students’ success at both the undergraduate and postgraduate levels. In addition to ~ 15 years of teaching at a university level, she has supervised and mentored many students and trainees (MSc, PhD, Post doc fellows, BScN students at SLC, fourth year life sciences at Queen’s U as well as summer students). She has been teaching science courses:  Pathophysiology, Microbiology, Anatomy and Physiology and Clinical Chemistry for the Bachelor of Sciences in Nursing students at St Lawrence College since 2005. She is an established investigator with over 75 publications in peer-reviewed journals and her research is recognized internationally. She is an adjunct associate professor at the department of Biomedical and Molecular Sciences at Queen’s University and has several collaborative research projects within Queen’s as well as internationally. She is an Associate Editor of Thrombosis and Haemostasis Journal and a reviewer on a number of journals within her discipline. She is currently the chairman of the International Scientific Standardization Committee (SSC) on women’s Health Issues in thrombosis and Haemostasis.

Teaching Profile

Teaching philosophy and strategies:

My teaching philosophy is centered around the following 5 main points: A) simplifying difficult scientific concepts and continuously relating and linking these concepts to the immediate and remote applications to Human health and disease. B) adapting to the evolving needs of learners. C) building strong academic relationship with my students, continuously mentoring them to achieve excellence and pursue better career opportunities D) using my knowledge, experience, passion and enthusiasm fully inside the classroom to provide students with the best positive learning experience. E) fulfilling the vision and mission of my academic institution in producing high quality graduates that suit the dynamic professional landscape.

I believe science teaching explains the dynamics and the magnificent power of the human body and leads to advancement of knowledge about pathologies and subsequently management of different diseases. In teaching nursing students, I start by connecting the material I am trying to teach to what the students know already then putting things in a broader context, which I believe is a key to exploring its importance. I link basic science to clinical practice and always try to provide the best stimulating and engaging learning environment for students via providing examples and encouraging discussions.

I consider the transmission of knowledge is fundamental in the evolution of a society. Explaining the beauty of things is part of my job that I thoroughly enjoy. I use my comprehensive medical and scientific knowledge from over 20 years of experience. I make sure I am continuously well prepared for teaching sessions. I believe my passion and enthusiasm are critically important to my teaching; not only to stimulate interest and engagement inside classroom, but often play a role in shaping up students’ future choices and career plans. I continue to set up an example as a good educator to help build up strong students and future educators. I share my own professional experiences in the classroom and link it to theoretical and practical knowledge that I teach. I often found this helpful for students to relate to the work force and facilitate their future career plans. I always make sure I am approachable by my students, as I believe this is important to follow up on the teaching/ learning process.

My international experience has given me a unique opportunity to choose from different styles of teaching that suit the learning needs of my students, a capability of understanding diverse students’ cultures and allowed me to use my knowledge of different diseases that are uncommon in the Canadian environment to enrich students’ experiences. I pay attention to the social aspect of teaching; I provide an environment of comfort and respect to all students with their wide range of diversity, that helps instilling confidence in them and strengthening their abilities to progress and achieve high standards.

I effectively communicate with students inside and outside the classroom and strive to understand their evolving needs. I utilize different/ new teaching methods that suit the subject taught and constantly develop new methods that motivate students.

Over the years, I managed to build a reputation of excellent teaching and care for my students’ success that is well recognized by my students and colleagues. I continue through my students’ evaluations to promote this reputation for the benefit of students.

I give special attention to understanding policies and procedures of the education institution I am part of. I continue to work with the system and make continuous efforts to develop courses, curricula and teaching styles as these are keys to improving the learning environment.

Scholarship Profile

Scholarship interest and diverse expertise fall into all pillars of scholarships:

           Scholarship of discovery (research)

Dr. Othman has been studying the rare bleeding disorder known as PT-VWD with a defect in platelet GP1BA gene since 2000. She has established an online international database disease registry  www.pt-vwd.com and led an international project that examined the occurrence of this disorder and established its molecular diagnosis. With over 15 collaborators worldwide, she is a regular speaker at the International Society of Thrombosis and Haemostasis (ISTH) conference and an active member of its Platelet Physiology-SSC.  Dr. Othman was the first to describe a deletion mutation in the platelet GP1BA gene in this disorder and first to describe CAR receptor on blood platelets. She also studies the role of platelet GPIb alpha protein in haemostasis and beyond, and is currently characterizing further the mouse model for the platelet GPIb alpha protein defects. She has developed an interest in coagulopathy and prostate cancer and has investigated the use of the global haemostatic assay thromboelastography (TEG) to assess thrombosis risk stratification in patients under different therapies particularly those under androgen deprivation therapy and completed a longitudinal study in this regard. She also promotes the use of TEG in the obstetric fields and has used the technology in both clinical and animal studies in pregnancy complications such as pre-eclampia and recurrent pregnancy loss and in the context of oral contraceptive use.  Her efforts nationally and international has led to her appointment as the chairman of the International Scientific Standardization Committee (SSC) on women’s Health Issues in thrombosis and Haemostasis. Dr. Othman received funding over the years from the Canadian Hemophilia Society and Prostate Cancer Canada, Queen’s University and St Lawrence College

         Scholarship of teaching and learning

Dr. Othman aims to integrate research in the undergraduate years of the BScN program. She developed an undergraduate research elective course for the third year BScN at SLC which is considered one of a kind in Ontario Colleges. The course is based on coaching students to perform a compete research study starting with formulating a research question, reviewing literature, writing a proposal, designing a methodology, conducting a well-controlled experiment, generating data and analyzing them using sound statistical methods and making conclusions and discussing limitations. Students are required to present their research data in a poster and oral open mini symposia as well as writing research reports and manuscripts following specific author guidelines for a journal within a scope of their research discipline. Outstanding projects are provided with opportunities for further development, publications, and submission to local and national conferences. The course has gained popularity over the past four years and has served research training for over 50 students. In this regard, Dr. Othman is a featured speaker on The annual "5th World Congress on Nursing & Healthcare" November 12-14, 2018.

More recently, and in collaboration with Dr. Nancy Sears, she initiated and completed a systematic study to investigate the relationship between the results of the NCLEX-RN exam and the performance of students in the undergraduate courses.  Phase 1 of the study was  completed by a systematic literature review was published in 2015 in more recently phase II was also completed by a published report in 2017 with the following title:  Canadian NCLEX-RN outcomes: A two-year cross-sectional exploratory study in Ontario.

Dr. Othman continues to develop her teaching materials, style and delivery and adjust it to the evolving dynamic earning needs for her students. She continuously strives to create new learning opportunities for her students. Her new elective course on ‘ Basic and Clinical Immunology” based on SGL, has just came to full fruition and will be offered in winter 2019.

        Scholarship of Integration and Application

As an associate editor in Seminars Thrombosis and Haemostasis journal, she is also responsible for guest editing at least one issue (10-14 chapters)/ 2years. This themed journal generates review articles to update the international haemostasis community about the recent findings in bleeding and clotting disorders. This knowledge dissemination is a key in transforming knowledge and experiences among physicians, specialists, researchers, students and trainees that ultimately help guide evidence based practice and/or direct a change in practice. Her responsibility is to select authors and coauthors, topics, invite participation, review/edit all articles and establish the issue contents, write the preface and plan the cover page and work with all corresponding authors and the publisher on the proof reading of all articles. She is also affiliated with the following international bodies: a member of an international working group for standardization of TEG assays and the GP1BA gene curator for the international ISTH Thrombogenomics Committee. This committee works to establish a platform to serve genetic diagnosis of bleeding and platelet function defects world-wide.  Both committees/ groups aid the development and standardization of assays that serve better clinical diagnosis and management of bleeding disorders. Dr Othman is a reviewer on several national and international research grants. And is a regular reviewer for several international peer-reviewed journals: Platelets J, Thrombosis & Haemostasis J, Thrombosis Research J, Journal of Thrombosis and Haemostasis, BMC Pregnancy and Childbirth, Blood Coagulation and Fibrinolysis and several others. Dr. Othman assumes several other international leadership roles. Examples are: member on the International Scientific Committee for 8th International Symposium on Women's Health Issues in Thrombosis and Haemostasis, March 29-31, 2019, Madrid, Spain and the International Advisory Board for the XXVII Congress of the ISTH and 65th Annual Scientific and Standardization Committee (SSC) Meeting, Melbourne, Australia.

Publications (past 10 years)

2018

Murray E, Murphy, M, Smith G, Graham C, Othman M. Thromboelastographic analysis of haemostasis in pre-eclamptic and normotensive pregnant women. Blood Coagul Fibrinolysis. 2018 Sep;29(6):567-572.

Borhany M, Fatima N, , Shamsi A, Othman M. Application of the ISTH bleeding score in hemophilia. Transfus Apher Sci. 2018 Jun 15. pii: S1473-0502(18)30030-2. doi: 10.1016/j.transci.2018.06.003.

El Masry S, Azzam H, Youssef H, Othman M, Awad M. Reduced Protein C Global Assay Levels in Infertile Women with in vitro Fertilization Failure: A Pilot Study. Acta Haematol. 2018 Jan 5;139(1):1-6.

2017

Othman M, Emsley J. Gene of the issue: GP1BA gene mutations associated with bleeding. Platelets. 2017 29:1-5. Invited review article

Kaur H, Corscadden K, Ware J, Othman M. Thrombocytopathy leading to impaired in vivo haemostasis and thrombosis in platelet type von Willebrand disease. Thromb Haemost. 2017 Feb 28;117(3):543-555.

Sears N*, Othman M*, O’Neil L, Hopman WM. Canadian NCLEX-RN outcomes: A two-year cross-sectional exploratory study in Ontario. Journal of Nursing Education and Practice JNEP 2017; 7(10): 36-45. PI and equal contribution*

Kaur H, D. Siemens R, Black A, Robb S, Barr S, Graham CH, Othman M. Effects of androgen-deprivation therapy on hypercoagulability in prostate cancer patients: a prospective, longitudinal study. Canadian Journal of Urological Association Journal CJUA 2017;11 (1-2):33-38.

Abd El-Latif M, Azzam A. Othman M, Warda O, El-Sharawy S, Ghoneim H, Assessment of annexin A5 and annexin A2 levels as biomarkers for pre-eclampsia: A pilot study. Pregnancy Hypertension, 2017;(8), 65-69.

Othman M, Kaur H. Thromboelastography. In: Methods in Molecular Biology, Hemostasis and Thrombosis. Methods and Protocols. Editors: Favaloro, Emmanuel J., Lippi, Giuseppe (Eds.) 2017;1646 pp 533-543. Springer, Online ISBN 978-1-4939-7196-1

2016

Sánchez-Lueros A, Woods A, Bermejo E, Shukla S, Acharya S, Lavin M, Rydz N, Othman M. PT-VWD posing diagnostic and therapeutic challenges- small case series. Platelets, 2016 Nov 7:1-7.

Othman M, McLintock C, Kadir R. Thrombosis and haemostasis related issues in women and pregnancy. Semin Thromb Hemost. 2016 Oct;42(7):693-695.  Preface author and Guest editor for the issue (12 chapters)

Alkhiary W, Azzam H, Yossof MM, Aref S, Othman M, El-Sharawy S. Association of hemostatic gene polymorphisms with early-onset ischemic heart disease in Egyptian patients. Clin Appl Thromb Hemost. 2016 Sep;22(6):535-42.

Othman M, Kaur H, Favaloro EJ, Lillicrap D, Di Paola J, Harrison P, Gresele P; Subcommittees on von Willebrand disease and platelet physiology. Platelet type von Willebrand disease and registry report: communication from the SSC of the ISTH.J Thromb Haemost. 2016 Feb;14(2):411-4. 7 years’ International Project Leader, PI & corresponding author

Othman M, Hopman WM, Sawyer V, Kerr C. Elective applied research course: A motivational approach to enhance learning. Journal of Nursing Education and Practice 2016; 6(4): 9-16.

Pettigrew S, McIntoch C, Othman M. Patients perspectives on urgent care centres’ wait times.  Health Care Information and Communication; the official journal of COACH, Feb 2016, vol 30 #2.

Sistoso M & Othman M. Post-secondary Students’ Perception of Flu Immunization. Health Care Information and Communication; the official journal of COACH. Feb 2016, Vol 30 #3: 31 – 34.

Kaur H, Corscadden K, Lott C, Elbatarny HS, Othman M. Bromelain has paradoxical effects on blood coagulability: a study using thromboelastography.  Blood Coagul Fibrinolysis. 2016 Oct;27(7):745-752.

Kaur H, Borhany M, Azzam H, Costa-Lima C, Ozelo M, Othman M. The utility of International Society on Thrombosis and Haemostasis-Bleeding Assessment Tool and other bleeding questionnaires in assessing the bleeding phenotype in two platelet function defects. Blood Coagul Fibrinolysis. 2016 Jul;27(5):589-93.

Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJ, Westbury SK, Greene D, Papadia S, Alessi MC, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve A, Guerrero J, Hampshire DJ, Hart DP, Heemskerk JW, Henskens YM, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, Lopez J, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina M, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet C, Whitehorn D, Wilcox DA, Zhang B, Revel-Vilk S, Gresele P, Bellissimo D, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E. A comprehensive high-throughput sequencing test for the diagnosis of inherited bleeding, thrombotic and platelet disorders. doi: 10.1182/blood-2015-12-688267. Blood; 2016 Jun 9;127(23):2791-803.

Kasawara KT, Cotechini T, Macdonald-Goodfellow SK, Surita FG, Pinto E Silva JL, Tayade C, Othman M, Ozolinš TR, Graham CH. Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats. PLoS One. 2016 Apr 28;11(4):e0154405.

2015

Alkhiary W, Azzam H, Yossof MM, Aref S, Othman M, El-Sharawy S (2015). Association of Hemostatic Gene Polymorphisms With Early-Onset Ischemic Heart Disease in Egyptian Patients.Clin Appl Thromb Hemost. Feb 18 [Epub ahead of print]

Arbelaez A, Niemann J, Freney R, Othman M, Emsley J, Mohammed S, Favaloro EJ.'Bleeding in the Jungle' (2015). Am J Hematol. Apr 8 [Epub ahead of print]

Maceachern K, Kaur H, Toukh M, Mumal I, Hamilton A, Scovil S, James P, Elbatarny HS, Othman M (2015). Comprehensive Evaluation of Hemostasis in Normal Women: Impact on the Diagnosis of Mild Bleeding Disorders. Clin Appl Thromb Hemost. 21(1):72-81.

Derman BA, Kwaan HC, Elbatarny M, Othman M (2015). Nitric Oxide, Coagulation and Cancer. Chapter in Nitric Oxide and Cancer: Pathogenesis and Therapy. Editors: Bonavida, Benjamin (Ed.) Springer. ISBN 978-3-319-13611-0

2014

Kaur H, Corscadden K, Lott C, Elbatarny HS, Othman M. (2014) Bromelain has paradoxical effects on blood coagulability: a study using thromboelastography. Blood Coagul Fibrinolysis; Dec 16. [Epub ahead of print]

Kaur H., Ozelo M, Scovil S, James P, Othman M (2014). Systematic analysis of bleeding phenotype in PT-VWD compared to type 2B VWD using an electronic bleeding questionnaire. Clin Appl Thromb Hemost; 20(8):765-771

Toukh M, Siemens DR, Black A, Robb S, Leveridge M, Graham CH, Othman M. (2014). Thromboelastography identifies hypercoagulablilty and predicts thromboembolic complications in patients with prostate cancer. Thromb Res; 133(1), 88-95.

Othman M, Emsley J. (2014). Platelet-type von Willebrand disease: toward an improved understanding of the "sticky situation. Semin Thromb Hemost; 40(2), 146-150.

2013

Othman M, Kaur H, Emsley J. (2013). Platelet-type von Willebrand disease: new insights into the molecular pathophysiology of a unique platelet defect. Semin Thromb Hemost. 39(6), 663-673.

Scepansky E, Othman M, Smith H. (2013). Acquired von Willebrand Syndrome with a Type 2B Phenotype: Diagnostic and Therapeutic Dilemmas. Acta Haematol. 131(4), 213-217.

Othman M. (2013). Rare bleeding disorders: genetic, laboratory, clinical, and molecular aspects. Preface. Semin Thromb Hemost, 39(6):575-578 

Toukh M, Ozelo MC, Angelillo-Scherrer A, Othman M.  (2013). A novel use of thromboelastography in type 2B von Willebrand disease. International Journal of Laboratory Haematology, 35(6), e11–e14.

Toukh M, Gordon SP, Othman M. (2013). Construction Noise Induces Hypercoagulability and Elevated Plasma Corticosteroids in Rats. Clin Appl Thromb Hemost, 20(7):710-715

Gupalo E, Kuk C, Qadura M, Buriachkovskaia L, Othman M. (2013). Platelet - adenovirus versus inert particles interaction: Effect on aggregation and the role of platelet membrane receptors. Platelets, 24(5), 383–391.

Othman M, Kaur H, Emsley J. (2013). Platelet Type von Willebrand disease: New Insights into the Molecular Pathophysiology of a Unique Platelet Defect. Semin Thromb Hemost. 39(6):663-673.

2012

Enayat S, Ravanbod S, Rassoulzadegan M, Jazebi M, AlaF, Emsley J, Othman M. (2012). A novel D235Y mutation in the GP1BA gene enhances platelet interaction with VWF in an Iranian family with Platelet type von Willebrand disease. Thromb Haemost, 108(5), 946-954.

Cotechini T, Othman M, Graham CH. (2012). Nitroglycerin prevents coagulopathies and foetal death associated with abnormal maternal inflammation in rats. Thromb Haemost, 107(5), 864-874.

Falcón BJ, Cotechini T, Macdonald-Goodfellow SK, Othman M, Graham CH. (2012). Abnormal inflammation leads to maternal coagulopathies associated with placental haemostatic alterations in a rat model of foetal loss. Thromb Haemost, 107(3), 438-447.

Toukh M, Pereira EJ, Falcon BJ, Liak C, Lerner M, Hopman WM, Iscoe S, Fitzpatrick MF , Othman M. (2012). Continuous Positive Airway Pressure Reduces Hypercoagulability, as Assessed by Thromboelastography, in Severe Obstructive Sleep Apnea. Resp Phys and Neurobiol J., 183(3), 218-223.  

2011

Gupalo E, Buriachkovskaia L, Othman M. (2011). Human platelets express CAR with localization at the sites of intercellular interaction. Virol J. 8, 456

Othman M, Lopez JA, Ware J. (2011). Platelet-type von Willebrand disease update: the disease, the molecule and the animal model: Editorial. Expert Rev Hematol. Oct 4(5), 475-477.

Chegeni R, Vickars L, Favaloro EJ, Lillicrap D, Othman M (2011) Functional analysis of three recombinant A1-VWF domain mutants in comparison to wild type and plasma-derived VWF facilitates subtyping in type 2 von Willebrand disease. Thromb Res.;127(2):161-166 

Renaud SJ, Cotechini T, Quirt JS, Macdonald-Goodfellow SK, Othman M, Graham CH Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion (2011). J Immunol.;186(3):1799-1808

Chitlur M, Sorensen B, Rivard GE, Young G, Ingerslev J, Othman M, Nugent D, Kenet G, Escobar M, Lusher J. Standardization of Thromboelastography: A Report from the TEG-ROTEM Working Group (2011). Haemophilia;17(3):532-537

Hamilton A, Ozelo M, Leggo J, Notley C, Brown H, Frontroth JP, Angelillo-Scherrer A, Baghaei F, Enayat SM, Favaloro E, Lillicrap D, Othman M. (2011). Frequency of platelet type versus type 2B von Willebrand disease. An international registry-based study. Thromb Haemost, 105(3), 501-508.

Renaud SJ, Cotechini T, Quirt JS, Macdonald-Goodfellow SK, Othman M, Graham CH. (2011). Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion. J Immunol., 186(3), 1799-1808.

Othman M. (2011). Platelet-type Von Willebrand disease: three decades in the life of a rare bleeding disorder. Blood Rev., Jul(4), 147-153.

Qadura M, Waters B, Burnett E, Chegeni R, Hough C, Othman M, Lillicrap D. (2011). Immunoglobulin isotypes and functional anti-FVIII antibodies in response to FVIII treatment in Balb/c and C57BL/6 haemophilia A mice. Haemophilia, 17(2), 288-295.

2010

Othman M, Gordon SP, Iscoe S. (2010). Repeated inspiratory occlusions in anesthetized rats acutely increase blood coagulability as assessed by thromboelastography. Respiratory Physiology & Neurobiology, 2010, 61-66.

Othman M, Powell S, Hopman WM, & Lillicrap D. (2010). Variability of thromboelastographic responses following the administration of rFVIIa to haemophilia A dogs supports the individualization of therapy with a global test of haemostasis. Haemophilia, 16(6), 919-925. 

Othman M, Chirinian Y, Brown C, Notley C, Hickson N, Hampshire D, Buckley S, Waddington S, Parker AL, Baker A, James P, & Lillicrap D. (2010). Functional characterization of a 13 bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease.gene in type 1 von Willebrand disease. Blood, 116(18), 3645-3652.

Othman M, Falcon B, & Kadir R. (2010). Global Haemostasis in Pregnancy: Are we Utilising Thromboelastography to its Full potential? Semin Thromb Haemost, 36(7), 738-746.

Othman M. (2010). Global Haemostasis: New approaches to patient diagnosis and treatment monitoring.  Semin Thromb Hemost. 36(7), 695-698.

Othman M. & Hamilton. (2010). Platelet-type von Willebrand disease: results of a worldwide survey from the Canadian PT-VWD project. Acta Haematol. 123(2), 126-128.

2009

Othman M, Chirinian Y, Hegadorn C, Powell S, Hopman W, Lillicrap D. Thromboelastography reflects global hemostatic variation among severe haemophilia A dogs at rest and following acute exercise. Hemophilia 2009; 1-9

Othman M, Favaloro EJ. Genetics of type 2B von Willebrand disease: "true 2B," "tricky 2B," or "not 2B." What are the modifiers of the phenotype?. Semin Thromb Hemost. 2008;34(6):520-531

Qadura M, Waters B, Burnett E, Chegeni R, Bradshaw S, Hough C, Othman M, Lillicrap D.  Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice. Blood 2009; 114(4):871-880

Othman M, Renaud S, Quirt J, MacDonald-Goodfellow S, Graham C. Thromboelastogrpahy Reveals Kinetics of LPS-Induced Coagulopathy and Correlates to Fetal Outcome in a Rat Model of Pregnancy Complications. Blood 2009; 114 (22), 4200-4200

Othman M, Chegeni R, Vickars LM, Favaloro EJ, Lillicrap D. Functional Characterization of Three VWF-A1 Domain Mutations Causing Type 2 Von Willebrand Disease. Blood 114 (22), 1305-1305

2008

Qadura M, Othman M, Waters B, Chegeni R, Walker K, Labelle A, Ozelo M, Hough C, Lillicrap D. Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells. J Thromb Haemost 2008 ;6(12):2095-2104

Ozelo MC, Zapata Esp R, Qadura M, Chegeni R, Othman M. Molecular genetic testing of hemostasis and thrombosis in developing countries: achievements, hopes, and challenges. Semin Thromb Haemost 2008;34(6):569-578

Othman M. Molecular genetic testing in hemostasis and thrombosis: the past, the present, and the future. Semin Thromb Hemost. 2008;34(6):485-489

Othman M. Differential identification of PT-VWD from type 2B VWD and GP1BA nomenclature issues. British Journal of Haematology, 2008;142: 308–326

 

Website

https://dbms.queensu.ca/faculty/maha_othman

www.pt-vwd.com